Acute Seizures in Old Age and Cognitive Dysfunction
Sook Young Roh, MD, PhD
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea
ABSTRACT
Acute seizures in old age are associated with cognitive dysfunction. Neurodegeneration or age-related hippocampus changes and underlying vascular pathologies including white matter disease, silent infarction or microbleeding may contribute to the development of seizures in dementia. However, recent data suggested that high levels of amyloid β induces aberrant excitatory neuronal activity in Alzheimer disease and leads to an epileptiform activity, even at early stages of the disease process and in the absence of overt neuronal loss. Adequate early application of both anticonvulsants and neuroprotective treatments of acute seizures in old age with dementia is critical for preventing the extent of acute seizure activity-mediated cognitive dysfunction in the aged population.
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