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J Neurocrit Care 2009;2(Suppl 2): 62-67.
저체온 요법
서울대학교 의과대학 분당서울대학교병원 뇌졸중 센터, 신경과학교실
Therapeutic Hypothermia
Moon-Ku Han, MD
Department of Neurology, Stroke Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
Background: Hypothermia is being used with increasing frequency to prevent or mitigate various types of neurologic injury. In addition, symptomatic fever control is becoming an increasingly accepted goal of therapy in patients with neurocritical illness. However, effectively controlling fever and inducing hypothermia poses special challenges to the intensive care unit team and others involved in the care of critically ill patients. Objective: To discuss practical aspects and pitfalls of therapeutic temperature management in critically ill patients.
Results: Cooling can be divided into three distinct phases: induction, maintenance, and rewarming. Each has its own risks and management problems. A number of cooling devices that have reached the market in recent years enable reliable maintenance and slow and controlled rewarming. Rapid induction decreases the risks and consequences of short-term side effects, such as shivering and metabolic disorders. Cardiovascular effects include bradycardia and a rise in blood pressure. Hypothermia's effect on myocardial contractility is variable (depending on heart rate and filling pressure); in most patients myocardial contractility will increase, although mild diastolic dysfunction can develop in some patients. A risk of clinically significant arrhythmias occurs only if core temperature decreases below 30℃. The most important long-term side effects of hypothermia are infections (usually of the respiratory tract or wounds) and bedsores.
Conclusions: Temperature management and hypothermia induction are gaining importance in critical care medicine. Intensive care unit physicians, critical care nurses, and others (emergency physicians, neurologists, and cardiologists) should be familiar with the physiologic effects, current indications, techniques, complications and practical issues of temperature management, and induced hypothermia. In experienced hands the technique is safe and highly effective.
Key Words: Hypothermia·Therapeutic·Definitions·Fever control·Normothermia·Side effects·Neurologic injury·Cardiac arrest· Traumatic brain injury
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Mild Therapeutic Hypothermia in Cardiac Arrest  2010 December;3(Suppl 2)
Therapeutic Hypothermia in the Intensive Care Unit  2014 June;7(1)
Physiologic Mechanism of Therapeutic Hypothermia  2014 June;7(1)
Therapeutic Hypothermia in Neurologic Diseases  2008 November;1(1)
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