Relationship between Metabolic Syndrome and Intracranial Atherosclerosis According to Age
Eun Joo Chung, MD1, Xuexiu Li, MD2, Jung Hwa Seo, MD1, and Eung-Gyu Kim, MD, PhD1
1Department of Neurology, Inje University College of Medicine, Busan Paik Hospital, Busan, Korea, 2Department of Neurology, Beijing Capital Medical University, Sanbo Brain Hospital, Beijing, China
ABSTRACT
Background: Although metabolic syndrome (MetS) is associated with intracranial large artery disease (IC-LAD), no systematic study has been conducted according to patient age. Thus, we evaluated the association between MetS and IC-LAD according to age. Methods: Acute ischemic stroke patients over 40 years of age with IC-LAD confirmed by CT angiography were enrolled. The patients were divided into 2 groups according to age, with 65 as the cut-off point. Vascular risk factors and laboratory results were compared between the two groups, and multivariate analysis was performed to verify the independent factors associated with IC-LAD. Results: One hundred and sixty-one patients had IC-LAD. The older patients (>65 years) had higher systolic blood pressure (SBP) (P=0.041) and triglyceride (TG) (P=0.0146). In the older group, there was a high prevalence of women (P=0.0006), nonsmokers (P=0.0001) and multiple (≥2) numbers of IC-LADs (P=0.0094). In the multiple logistic regression analysis for each component of MetS as a risk factor of IC-LAD, diabetes mellitus (DM) (P=0.0407) and high TG (≥150) (P=0.018) were significantly correlated with IC-LAD in the older group. Conclusions: High SBP and TG are predominantly observed in elderly patients. In particular, the older group has a high prevalence of women, nonsmoker and multiple IC-LADs (≥2). Among the components of MetS, DM and high TG are important risk factor for IC-LAD in the older group.
PDF Links
Full text via DOI 
Download Citation 
