Diffuse microbleeds in cerebral white matter have been reported in critically ill patients [1]. We present a case of extensive microbleeds in the bilateral cerebellum and pons accompanied by sepsis. A 16-year-old female patient complained of severe headache, dizziness, and drowsiness while being admitted for treatment of cellulitis of the left malleolus. She was diagnosed with juvenile rheumatoid arthritis and treated with immunomodulators (sulfasalazine 500 mg and prednisolone 7.5 mg) for 5 years. Three hours after the first complaint of headache and dizziness, she presented with right hemiparesis with stuporous mentality, eventually progressing to coma. Although brain computed tomography images did not show hemorrhage, T2*-weighted gradient echo magnetic resonance imaging revealed massive microbleeds confined mainly to the bilateral cerebellum and brainstem (Fig. 1). Despite intensive care, the patient died of sepsis and extensive brain edema.
Microbleeds in the brain are detected in conditions such as microangiopathy, Moyamoya disease, vasculitis, and posterior reversible encephalopathy syndrome [2]. Meanwhile, Thurnher et al. [3] reported diffuse microsusceptibility changes, including in the brainstem and cerebellum, in critically ill immunocompromised patients undergoing mechanical ventilation and oxygenation. In our case, the precise diagnostic evaluation of other diseases that can provoke massive microbleeds and brain edema was not possible due to the patient's critical condition. However, images presenting with normal angiography and the absence of antibodies associated with vasculitis could indicate a condition prone to microbleeds in the brainstem with secondary brain edema due to the critically ill state.
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