A Case of Clinically Reversible Wernicke Encephalopathy in Spite of Extensive Cortical Involvement and Seizure
Sung Geun Ryu, MD and Se-Jin Lee, MD, PhD
Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea
ABSTRACT
Background: There have been few reports of reversible Wernicke encephalopathy with extensive cortical involvement. Case Report: A 57-year-old female, a chronic alcohol-abuser, presented with acute confusional state, ataxia, ophthalmoplegia and seizure. Brain magnetic resonance imaging showed brain lesions at the bilateral periaqueductal gray matter, mammillary bodies and median thalami, which were indicative of Wernicke encephalopathy. In addition, extensive symmetric frontal cortical lesions were observed. After administration of intravenous thiamine, the patient recovered almost completely. Conclusions: A patient with Wernicke encephalopathy complicated by extensive cerebral cortical lesion may recover after appropriate treatment.
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